For greater than a century, scientists have seen water has quite a lot of uncommon properties that don’t match inside the basic mannequin of it being only a strong, liquid or gasoline.
Gerald Pollack constructed upon these observations, and ultimately decided that when a negatively charged floor is current, if an applicable power supply can also be current (significantly infrared — which is in all places), the water will assemble itself into layers of offset hexagonal sheets with the method H3O2 that behave like a liquid crystal.
Be aware: Along with gentle, sound may generate H3O2.
In my eyes, liquid crystalline water is a critically underneath appreciated space of science because it offers a mechanism to clarify most of the unexplained mysteries of the physique (e.g., how achieve this many fluids circulate inside it regardless of there being no identified pump to maneuver them) and a method to put phrases into a lot of what we often observe inside the physique.
What Is Liquid Crystalline Water?
Liquid crystalline water has a major diploma of solidity, and can expel most issues from getting into it (e.g., polystyrene microspheres), together with the displaced hydrogen atoms (as it’s H1.5O not H2O). These displaced positively charged H atoms (henceforth known as protons), in flip assemble instantly exterior this lattice, thereby making a pH and cost gradient which could be measured.
In lots of instances, these H3O2 lattices could be monumental — in favorable circumstances, Pollack and others have measured ones starting from 0.1 millimeters to 0.5 millimeters (100,000 to 500,000 nanometers or nm) in measurement. Cells rely on this water, so that they include numerous surfaces from which the water can type.
For instance, 20% of the cell is occupied by its cytoskeleton (a protein lattice which maintains its construction), and evaluation of high-voltage electron micrographs have proven that inside the cytoskeleton, over half of the water current is inside 5 nm of a floor it may probably type H3O2 on (for reference a single H2O molecule is 0.27 nm in measurement).
Because the floor websites that water can construction on are so intently packed collectively in cells, it’s comprehensible why liquid crystalline water (additionally generally referred to as EZ water) could be a lot extra obvious to people observing dwelling cells underneath a microscope (which in truth is the place a lot of the early analysis on H3O2 originated from). This in flip raises one other query: why are cells designed to create a lot liquid crystalline water?
Be aware: An extended article describing the lengthy historical past of analysis into liquid crystalline water (H3O2) and its bodily properties could be learn right here.
Mysteries of the Cell
Within the earlier article, I mentioned a typical difficulty I observe inside science. When an incorrect mannequin is utilized to clarify a pure course of, discrepancies between the mannequin’s predictions and actuality will inevitably seem.
One would count on that when this occurs, it might encourage these espousing the inaccurate mannequin to re-examine their mannequin, however as an alternative, since a lot has been invested into that mannequin, they as an alternative will denounce any challenges to it, and give you innumerable inventive methods to clarify away every failure of the present mannequin.
Think about, for instance, the preliminary guarantees of the vaccines (if you happen to get two doses, you had been advised that you’d be utterly immune, transmission would cease, and COVID-19 would quickly fade into reminiscence). Because the medical trials for the vaccines had been fraudulent, not one of the vaccines’ guarantees materialized, and the COVID scenario as an alternative grew to become worse.
Nonetheless, as an alternative of healthcare authorities (and the medical neighborhood) admitting their mistake and switching to a distinct method for managing COVID-19, they doubled down on the vaccine mandates and moved the objective posts again and again with regard to what mass-vaccination (and boosting) was truly supposed to perform.
Likewise, for mobile biology, our data of the cell is surprisingly primitive and the present fashions usually fail to clarify what happens inside the mobile setting. Nonetheless, for the reason that different fashions should not usually accepted by the scientific neighborhood, we now have been compelled to repeatedly patch the present fashions in order that they’ll considerably account for the innumerable mysteries of life.
At this level, I consider one of many key causes of this case is scientific analysis turning into distorted to prioritize specializing in discoveries that trade can revenue from.
For instance, immunology has a slim concentrate on the elements of the immune system which could be focused by vaccination or proprietary medication, which in flip has left many different elements of the immune response uncared for (the immune system is often known as one of many least understood methods within the physique).
Equally, since pharmaceutical medication usually work by affecting receptors and channels in cells, mobile biology has adopted a narrow-minded concentrate on simply these elements of a cell.
In flip, the liquid crystalline part of water offers quite a lot of explanations for most of the organic phenomena that the present fashions merely don’t adequately deal with. On this article, I’ll focus upon a couple of of them.
Be aware: A lot of what’s mentioned on this article is roofed in additional element inside these three books (equally, the vast majority of the references for this text are sourced from these books, so I can’t repetitively cite them all through the article). In case you want to additional examine the topic your self, I might advocate studying these books (all authored by Gerald H. Pollack) on this order:
- The Fourth Section of Water: Past Strong, Liquid, and Vapor (2013)
- Cells, Gels and the Engines of Life: A New, Unifying Strategy to Cell Operate (2001)
- Section Transitions in Cell Biology (2008) — that is probably the most technical of the three
Mobile Integrity
One of many main puzzles of biology is the immense sturdiness that cells have. In case you contemplate the basic mannequin — cells being baggage of liquid contained inside a fluid mosaic membrane, it needs to be easy for exterior forces to “pop” cells and have all of their contents spill out. But typically, cells preserve their integrity regardless of important stressors.
Cells can survive traumas, together with being guillotined in half, drawn and quartered (so particular elements could be remoted and labored with — similar to when performing in vitro fertilization), or shot stuffed with holes with electrical bullets, every of which one would count on could be enough to “pop” them. Nonetheless, in every occasion, mobile integrity of the remaining part persists.
Equally, if the membrane from a cell is eliminated, its inside contents stay in place relatively than quickly dispersing. It has additionally been identified for over 50 years that if muscle fibers lose their membranes, their useful means (making a contractile drive) stays intact.
Three clues assist to clarify these phenomena. The primary is that — as Pollack has proven — water droplets have a exceptional quantity of integrity, and like cells, will preserve their integrity (and subsequently fuse again collectively) if a micro-blade is used to guillotine them in half. The second is that Pollack has additionally proven water droplets include a major diploma of liquid crystalline water which possible is what confers their integrity.
The third is that the water molecules in cells predominantly exist inside gels, that are composed of that very same liquid crystalline water. Put otherwise, which means that a cell’s stability is basically a property of its water holding it collectively relatively than the exterior construction which encapsulates it.
One other necessary facet of mobile structure ought to now be thought-about. Because the circumstances for liquid crystalline water formation are current all through the cell (negatively charged hydrophilic surfaces and ambient infrared power), the cells ought to quickly be filling themselves with liquid crystalline water layers a whole lot of micrometers in thickness.
But, all through the cells, the surfaces are sometimes solely fractions of a micrometer aside. Which means the construction of the cell relies upon upon the continuous formation of liquid crystalline water, however concurrently constrains that crystalline construction from rising to its full measurement.
Tensegrity
Classically in structure, buildings are created by having robust skeletons upon which the remainder of the construction rests. For instance, within the previous days, we often used stone pillars; these days, skyscrapers require metal superstructures to fulfill the wants of those buildings:
This mannequin usually doesn’t work inside dwelling organisms, as a result of life, not like these buildings, requires fast motion, and dwelling organisms merely can’t produce strong constructions with the identical power as metal beams. Nonetheless, an alternate and extra advanced architectural mannequin has been developed which is often utilized by those that embrace complexity inside their fashions.
Tensegrity (brief for tensional integrity), was a mannequin first put ahead by Buckminster Fuller. It posits that if a sequence of non-compressible constructions are linked collectively by a lattice of elastic connections (which may retailer rigidity when stretched), a a lot stronger construction is created.
It’s because any drive the construction receives will likely be equally distributed by means of every of these elastic connections relatively than concentrating on a single part (e.g., the stone pillar), and thus, a lot much less prone to exceed the breaking level of any single structural part.
Fuller’s work subsequently impressed quite a few buildings to be constructed on the rules of tensegrity. This can be a basic image of him holding a tensegrity sphere he made:
Biotensegrity encapsulates the belief that this similar system additionally happens all through nature. For the human physique, at every stage of group, a linked tensile matrix is current that confers its stability.
One French hand surgeon, Jean-Claude Guimberteau, has likewise completed a exceptional job of demonstrating the presence of linked tensile constructions on the stage of fascia (a connective tissue current all through the physique many handbook therapists work with), by means of small (magnified) cameras positioned within the physique throughout minimally invasive surgical procedures:
Be aware: On the magnification scale used right here and in his different movies, liquid crystalline water could be instantly noticed coating these constructions. Additionally be aware its lubricating high quality that enables the constructions to slip previous one another. Lack of this lubrication seems to create quite a lot of points inside the physique.
Because the years go by, there seems to be a larger consensus inside the holistic medical discipline that biotensegrity is a sound mannequin for understanding the physique, and that linked networks of rigidity are current from the biggest to the smallest ranges of the physique (e.g., the cytoskeleton is the elastic connecting unit inside every cell). Nonetheless, whereas this concept is often mentioned, there are nonetheless two main unaddressed points with it, which I consider liquid crystalline water can clarify.
The primary is that in Guimberteau’s work, he had noticed that tiny vacuoles (enclosed compartments crammed with water) all through the physique type the essential incompressible unit that a lot of the physique’s tensegrity relies upon upon.
The second is that at a good increased magnification inside cells, whereas a cytoskeleton is current that’s underneath rigidity, there may be nothing that may be seen which creates that rigidity (and it’s extremely debatable if the cell’s connections to the extracellular matrix suffice to create that rigidity). This issues as a result of the structural power of a tensegrity system solely emerges when a construction’s elements are underneath rigidity.
Within the case of the previous, I consider that the microvacuoles are crammed with liquid crystalline water (which can’t be compressed). Within the case of water droplets, Pollack concluded that the mutual repulsion between positively charged protons (pushed to the middle of the droplet by sheets of H3O2) creates an outwards drive resisted by the liquid crystalline boundary of the droplet.
The stability between these two forces ends in the droplet assuming a spherical type, and I consider the identical mechanism is at work within the microvacuoles all through the human physique.
Within the case of the latter, it is very important bear in mind how a lot enlargement is produced by proteins that create gels (many gels are over 99.9% water). Pollack, in flip, has proven that the liquid crystalline water that’s continually making an attempt to type inside the cell is unable to succeed in its full measurement as a result of proteins resisting the stretch that must happen had been the liquid crystalline gel to develop to its full measurement.
This occurs each on the stage of the cell (because the cytoskeleton stretches because the cell expands to its most measurement, till it can’t enable additional enlargement to happen) and inside proteins all through the cell.
On the protein stage, the physique usually depends upon chemical bonds to be made between proteins to constrain the utmost enlargement that may happen in response to a gel forming. Moreover, proteins can alternate between a folded and an unfolded conformation (e.g., a helix vs. a coil), one thing usually decided by the strain utilized to the protein (such because the expansive stress of liquid crystalline water inside a gel).
There are a selection of significance penalties of this conformation change which will likely be mentioned later on this article (e.g., for the physiology of muscle tissue). Moreover, many different elements of the physique additionally seem to depend on liquid crystalline water:
“Finding out collagen, Melacini et al. famous the significance of water in stabilizing its triple helix crystalline construction. They discovered that water inside the collagen helix types a “semi-clathrate-like construction that surrounds and interconnects triple helices within the crystal lattice.”
Water inside the matrix of bone is likewise extremely structured, a structuring that has been discovered related not solely with natural macromolecules similar to collagen and proteoglycans, however with the mineral surfaces as nicely. Water, in truth, appears to play a foundational function in orienting mineral nanoparticles into parallel preparations inside the bone matrix, offering this orientation even within the absence of natural molecules.”
On a regular basis Gel Expansions
Many applied sciences we’re conversant in (e.g., diapers) depend on hydrogels which may increase right into a semisolid construction which retain water. Equally, we are able to instantly observe that many bigger processes inside the physique are additionally dependent upon water’s tendency to assemble into the bigger liquid crystalline constructions.
As a result of the conventional structure of protein’s cross-linking habits limits how a lot gels can increase (because the proteins which would wish to separate to accommodate the rising gel are prevented from doing so by cross hyperlinks between them), when tissue or protein is broken, this limitation could be partially eliminated. In consequence, it may be seen on a microscopic scale that human tissue will swell and increase when it’s broken.
Likewise, Pollack has argued that that is almost definitely what occurs while you expertise a musculoskeletal trauma. In Pollack’s proposed mannequin, the preliminary gel formation additional expands the present tear, and this progressive enlargement of liquid crystalline water ultimately results in seen swelling.
On a bigger scale, one of many main engineering challenges for the physique is having weight-bearing joints just like the knees have the ability to preserve their vary of movement with out turning into broken by the continuous friction they expertise every day.
A exceptional attribute about liquid crystalline water is that, offered the floor from which it types stays intact, liquid crystalline water could be destroyed after which reform, together with its virtually frictionless floor, again and again.
Due to this, the liquid crystalline water finally ends up being the part which absorbs the stress skilled by wholesome joints, and offered the joint is wholesome, this water can immediately regenerate from that stress. Along with this regenerating layer of negatively charged liquid crystalline water, on the very heart of the joint, there’s a pocket of positively charged protons which repel from one another and create an expansive stress (like what’s seen in a water droplet).
Because the joint capsule seals this area, these protons are unable to flee and thus successfully perform like repelling magnets (e.g., contemplate a maglev prepare) that resist the load of the physique and preserve the central area inside the joint.
One of many issues I contemplate probably the most compelling about Pollack’s mannequin for the joints is the precise high quality of synovial fluid contained in the knee joint. Once you view it on a digital camera throughout an arthroscopic surgical procedure, diffusion inside it’s visibly slowed, whereas if you happen to instantly extract it (e.g., throughout a knee aspiration), you may inform that it has a a lot thicker and gelatinous high quality, one thing I’ve realized to affiliate with the presence of liquid crystalline water.
Pollack likewise argues that his mannequin suggests EZ (liquid crystalline) water’s habits resembles that of a gelatinous egg white which is semisolid when left alone, but in a position to circulate in response to an imposed shear drive.
Mobile Gradients
Be aware: A “gradient” describes a distinction within the focus of issues in two completely different areas. This might embody electrical prices (i.e. batteries depend on gradients), electrolytes, or temperatures — and plenty of gradients present an simply harvestable supply of power.
The present paradigm of physics asserts the next:
- The pure state of issues is to be disordered and evenly combined.
- Anytime you make one thing turn out to be extra ordered (e.g., forming a crystal or making a gradient between two areas), power have to be expended to create that ordering.
- When an ordered construction turns into disordered, power is launched within the course of which may generally be harvested (e.g., combusting wooden in a wooden range to warmth our properties).
- Anytime power is launched from one thing, if you happen to try to seize and retailer that power, some power will at all times be misplaced.
These legal guidelines, in flip, are used to refute the likelihood that any kind of “free-energy” system can exist, such because the exclusion zone (EZ) water system Pollack has proposed the place quite a few harvestable gradients are created. Sadly for the present paradigm, biology usually seems to violate these legal guidelines, as it’s frequently shifting in direction of a extra ordered state relatively than the disordered state the present paradigm predicts.
The present decision for this paradox (which gained a Nobel prize) is that dwelling organisms perform as “dissipative constructions,” which trade the order in giant quantities of ordered elements they accumulate from their setting in return for imparting order to their very own disordered contents.
Though to some extent this enables the present paradigm to maintain itself, I don’t consider it’s fully correct as water, by means of its liquid crystalline construction, has the flexibility to retailer radiant power that passes by means of it and convert that power to order the physique can then make the most of.
The Sodium Potassium Gradient
One of many issues dwelling cells are well-known for doing is concentrating potassium inside themselves and reciprocally expelling sodium. Because the focus inside and out of doors cells differs, a gradient exists, which, by the present legal guidelines of physics ought to attempt to equalize itself and quickly disappear.
Since this doesn’t occur, the present mannequin has argued that the mobile membrane prevents the passage of most however not all sodium and potassium (thereby inhibiting the gradient from equalizing itself) and that sodium potassium pumps on the mobile membrane exist which continuous swap sodium contained in the cell for potassium exterior the cell.
As a result of this trade is so very important to sustaining the well being of the cell, a big focus in mobile biology is positioned on the significance of the sodium potassium trade pump. Sadly, there are three basic issues with this mannequin (the proof of every of those and extra is introduced by Gilbert Ling right here):
- The mathematics doesn’t add up — the present sodium potassium pumps merely wouldn’t have the capability to counteract the pure undoing of the sodium and potassium gradients. For instance, in muscle cells, sustaining the sodium potassium gradient with pumps requires between 4 to 30 instances the whole out there power within the cell.
- Cells are in a position to preserve a gradient with quite a lot of different undesirable elements they expel (e.g., micro organism expelling antibiotics) and to clarify these phenomena, increasingly pumps are recognized to attempt to help the mannequin. This can be a downside as a result of it’s unlikely that cells have the capability to concurrently maintain so many various pumps.
- Ling took frog muscle cells whose setting was altered in order that they had been utterly starved of power (which is required to function the sodium potassium pump). Regardless of this, the gradient was maintained.
This then begs the query of what might be creating this gradient? Ling made the next observations:
- The gradient was maintained if the cell membrane (the place these pumps reside) was eliminated.
- Producing a membrane with sodium potassium pumps that didn’t include a cytoplasm (the within of a cell) resulted within the gradient quickly disappearing from with the membrane.
This means that the gradient is a property of the cell cytoplasm relatively than the mobile membrane. Curiously, the an identical property has been present in synthetic gels, which just like the cytoplasm, additionally generate giant quantities of liquid crystalline water:
“We present that the gel barrier is ready to preserve a secure separation of ionic options of various ionic strengths and chemical compositions with none pumping exercise. For the Na+ /Ok+ focus gradient sustained throughout the barrier, a detrimental electrical potential develops inside the Ok+ -rich facet. The scenario is harking back to that within the cell.
Moreover, additionally the advective circulate of water molecules throughout the gel barrier is restricted, regardless of the gel’s giant pores and the osmotic or hydrostatic stress gradients throughout it.”
This focus phenomenon has additionally been noticed by different authors:
“Proof for such accumulative condensation was produced virtually a century in the past when Bungenberg de Jong in 1932 confirmed that even dilute options of polymers, when shaken, coalesced into droplets-then referred to as coascervates-in which the natural matter grew to become extremely concentrated. The polymer focus in such droplets may exceed the focus within the surrounding tub by as a lot as 10,000 instances.
When positioned in sure dyes, the droplets grew to become progressively extra coloured, the depth usually many instances exceeding that of the encircling answer. Thus, gel droplets had the capability to pay attention sure solutes, because the cell concentrates potassium.”
Since gels independently display most of the inexplicable traits of cells, it’s thus affordable to conclude they may share a mechanism for producing the sodium potassium gradient noticed all through biology.
Obstacles
One main problem for all cells is holding undesirable issues out. Classically, we view the method of pathogenic substances getting into cells as being a product of their interplay with matching receptors on the cells (a world view which I consider is emphasised by medical science as a result of medication could be developed to disrupt this course of). I, in flip, consider that this exclusion course of by the cell is closely influenced by present prices, zeta potential and liquid crystalline water.
As a result of liquid crystalline water can for probably the most half solely type on negatively charged surfaces (the identical approach that water molecules every expel half a hydrogen atom and thereby maintain a web detrimental cost as a result of misplaced hydrogens), virtually each floor within the physique (and plenty of different pure methods) is coated with a detrimental cost.
Since colloidal stability (which governs the habits of most fluid methods) largely relies upon upon the mutual repulsion created by an identical prices, most pure colloidal methods make the most of detrimental prices to stay dispersed and solely clump collectively if extreme constructive prices are current (likewise most strategies of restoring zeta potential function on this precept).
Pathogenic organisms usually impart constructive prices to their setting (similar to by means of micro organism decarboxylating the detrimental prices of amino acids inside proteins). This causes proteins and cells contained in the physique to start clumping collectively (the malaria parasite is especially good at doing this), which each prevents the immune system from getting access to the microbes and will increase the microbe’s means to realize entry to the cells.
One of many significantly attention-grabbing observations made by the unique proponent of physiologic zeta potential was that bacterial and viral infections (I consider this was probably the most studied with influenza) would create a constant degradation of the physiologic zeta potential. This offers a proof for why viruses like influenza could be a lot extra harmful for the aged.
Somebody with a wholesome zeta potential can tolerate a minor impairment of their colloidal stability (they may simply really feel a bit unwell), however for somebody who already has an impaired zeta potential (which is a quite common consequence of ageing), that discount could be enough to cross a essential threshold the place extreme sickness onsets.
One of many earliest distinguishing traits of COVID-19 to me was that many sufferers developed medical indicators suggesting extreme zeta potential disruption, one thing I had not seen with every other respiratory virus. A key cause I used to be involved concerning the spike protein lengthy earlier than the vaccines entered the market, was as a result of I had recognized it because the possible perpetrator for this zeta potential disruption.
This was as a result of it being a novel part of the SARS-CoV-2 virus (it differed from that of SARS-CoV-1) that was current on the floor of the virus and which had an unusually excessive constructive cost density. It has since been proven that the spike protein instantly induces clumping of purple blood cells, possible as a result of its cost distribution having the potential to create a major disruption of physiologic zeta potential.
One of many attention-grabbing feedback I’ve repeatedly seen acknowledged by each people who’ve taken protocols to enhance their physique’s manufacturing of liquid crystalline water and people who’ve completed the identical for bettering their zeta potential, is that they not often get sick.
This might probably imply both that the signs of infections are far more minor if these physiologic parameters are already in good well being (e.g., because you don’t cross a essential zeta potential threshold), or as a result of they instantly stop cells from turning into contaminated by pathogens.
As many elements which positively have an effect on one of many parameters usually have an effect on the opposite (e.g., earthing improves zeta potential and promotes the expansion of liquid crystalline water within the physique), it’s a bit arduous to say which impact finally predominates, and an ideal deal of my analysis on this matter was primarily based on making an attempt to reply that query.
Be aware: The strategies of restoring zeta potential and rising liquid crystalline water inside the physique are mentioned additional right here.
On this article, we evaluation among the proof supporting that barrier speculation. The earliest I got here throughout was from the work of Viktor Schauberger (1885-1958), who believed it was critically necessary for water to journey in a vortexing sample, one thing as mentioned within the earlier a part of this sequence, has been proven to extend the presence of liquid crystalline water.
One of many many discoveries made by using vortexing methods primarily based on his design for water provides was that it decreased the expansion of micro organism inside the water system (e.g., on the within of pipes).
Different analysis has instantly discovered that the presence of liquid crystalline water prevents the expansion and invasion of micro organism, similar to this examine:
“In a take a look at carried out with E. coli, cells progressively penetrated EZ [liquid crystalline water] over 2 days. Moreover, EZ-bearing Nafion had 80% much less biomass accumulation of E. coli over 2 days in comparison with an EZ-less, hydrophilic, clean aluminum oxide floor. This means that EZ could symbolize the primary line of protection, spatially and temporally, towards micro organism approaching sure hydrophilic surfaces.
These findings may have necessary implications in growing biofouling-resistant materials surfaces for purposes delicate to bacterial attachment and biofilm formation.”
And this examine:
“Silk sericin is a globular protein whose resistance towards fouling is necessary for purposes in biomaterials and water-purification membranes. Right here it’s proven how sericin generates a water-exclusion [liquid crystalline] zone that will facilitate antifouling habits. Negatively charged microspheres had been used to imitate the floor cost and hydrophobic domains in micro organism.
Immersed in water, sericin shaped a 100-µm-sized exclusion zone (for micron-size foulants), together with a proton gradient with a lower of >2 pH-units. Thus, when involved with sericin, water molecules close to the floor restructure to type a bodily exclusionary barrier which may stop biofouling.
The decreased pH turns the aqueous medium unviable for neutrophilic micro organism. Subsequently, resistance to biofouling appears explainable, amongst different elements, on the idea of water-exclusionary phenomena.”
Many tissues rely on the presence of liquid crystalline water lining them, and that is possible a minimum of partly, as a result of protecting barrier they create. Inexperienced and Otori in 1970, for instance, discovered exclusion zones roughly 350 μm deep extending from the cornea, and likewise from contact lenses (it’s necessary to guard the attention from harm, and liquid crystalline water capabilities as a clear, well-lubricated barrier, qualities each essential for the eyes).
Pollack, roughly 15 years in the past, additionally discovered an identical outcomes (the presence of liquid crystalline water) subsequent to polyNIPAM, the gel used to manufacture contact lenses.
Some of the necessary tissues within the physique for offering a protecting (however well-lubricated layer) is on the endothelial lining of the blood vessels. There, giant quantities of blood creating important shear forces continually cross over the blood vessels. Up to now, Malcom Kendrick has famous that the areas of circulation which expertise the best shear forces are the almost definitely to develop the persistent harm which ultimately results in coronary heart illness.
The protecting coating of the endothelium, the glycocalyx, is structured (as a result of its excessive sulfate content material) to create giant quantities of gel (liquid crystalline water) round it and thus shield the endothelium. Moreover, a skinny layer that blood cells can’t enter is thought to instantly line the partitions of even the smallest blood vessels.
Equally, researchers in 2000 noticed a 0.4-0.5μm thick gelled layer of water lining the endothelium of wholesome capillaries (the smallest blood vessels within the physique), and this lining excludes quite a lot of completely different substances from reaching the endothelium.
Formally, the vaccine spike protein can’t have an effect on the endothelium as a result of it lacks a useful ACE2 binding area (whereas the COVID-19 virus has a useful one by means of which it then enters the cell).
Though that is the case, there are many different methods that the spike protein can nonetheless connect to the endothelium (e.g., the spike protein can nonetheless connect to the receptor, it instantly binds heparin within the glyocalyx, and whether it is produced from contained in the endothelium by the vaccine, it has successfully entered the endothelium).
Since autopsies of people suspected to have died as a result of vaccination have revealed profound harm to the endothelial layer, this offers robust proof that the spike protein in a method or one other has the flexibility to penetrate the usually protecting barrier there.
Many have suspected that that is partly as a result of extremely constructive cost that the spike protein (and the generally positively charged elements of the lipid nanoparticles) carries, as these constructive prices can penetrate the liquid crystalline water barrier defending cells just like the endothelium.
I consider it could even be as a result of spike protein’s disruption of zeta potential, as different states related to elevated blood viscosity (e.g., uncontrolled diabetes) are identified to harm the endothelium and speed up the development to heart problems.
Section Transitions
Though liquid crystalline water is critical for all times, an excessive amount of of it may also be problematic. For instance, if all the cell was lined with gel-state water, it might not be doable for a lot of issues that wanted to enter the cell to enter.
To unravel this downside, areas of constructive cost exist within the membrane (e.g., Pollack argues that it is a key cause for the position of steel ions inside the cell membrane), which stop liquid crystalline water from forming over the realm and thus create an open passage for water to journey by means of.
Be aware: Though we’re taught to think about the cell as a fluid mosaic of phospholipids with proteins right here and there, roughly 50% of the cell membrane is usually composed of proteins (and it could actually generally be much more).
Generally, nonetheless, the physique depends upon having the ability to rework water between its gel (liquid crystalline) state and a sol (bulk water containing colloidal suspensions) state as wanted. Nonetheless, whereas recognition of the basic significance of part modifications in mobile biology has step by step elevated during the last 70 years, the vast majority of the scientific discipline remains to be wedded to the fluid mosaic speculation, which believes that the mobile membrane is at all times a liquid.
Briefly, gels (each pure and artificial ones) usually have a temperature (its transition level) the place the gel will endure a fast transition from one state to the opposite (defined additional right here). So far as I do know, in all instances, the warmer temperature will correspond to the sol state (H2O water with suspended colloids) and the colder one will correspond to the gel state (H3O2). Moreover, elevated stress may also promote the gel state:
“Organic exercise virtually universally requires that membranes be of their fluid state; in lots of instances, simply above the transition level.”
Gels all through the physique, in flip, are designed to have a part transition level close to the conventional temperature of the physique. This will clarify why most mammals and birds preserve their temperature between 35°– 42°C (95°– 107.6°F; the conventional temperature for people is 37°C or 98.6°F), an in any other case curious reality given how a lot their our bodies and environments differ (e.g., a tiny chicken within the desert vs. a blue whale).
Moreover, this temperature extends past warm-blooded animals. A tuna fish, when lively, maintains the temperature of its physique at 30°C or 86°F (the ocean is far colder) whereas many reptiles preserve their physique temperature close to 40°C or 104°F (by doing issues like searching for out the solar). Many bugs additionally can’t fly till they’ve warmed as much as an identical vary of temperature (e.g., 38°C or 100.4°F for bumblebees).
Equally, the part transition level is closely influenced by the supplies that the gel builds from (e.g., elements of the cell membrane). Chilly-blooded animals in flip have been noticed to alter the composition of their cell membranes in response to their setting.
In a single experiment, Calotes versicolor (the frequent backyard lizard), had been acclimatized to 16°, 26°, and 36°C (60.8°, 78.8°, and 96.8°F) for a interval of thirty days. The lizards exhibited dramatic modifications within the focus of main phospholipids (elements of the cell membrane) similar to phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, cardiolipin, and sphingomyelin.
Temperature acclimatization has additionally been noticed to differ the lipid composition of carp muscle microsomes together with carp blood cells, and seasonal variation has been noticed within the lipid composition of brains of rainbow trout.
As soon as the gel is held close to its transition temperature, it’s then relative straightforward to alter precisely the place that transition temperature is so water could be stored within the applicable part for the present physiologic wants. That is primarily completed inside the physique by altering the electrolyte composition of the realm, as robust cations (positively charged ions) destroy gels, whereas robust anions (negatively charged ions) reinforce them.
So far as I can inform, the consequences of those ions correlate to the excessive valence (cost) anions (-) that almost all successfully help physiologic zeta potential and people excessive valence cations (+) which most successfully destroy it.
The first cation aspect which the physique makes use of to shift the transition temperature so as to destroy gels is calcium (Ca). As an instance the impact of calcium graphically (be aware how a sudden essential threshold of Ca focus is reached):
These outcomes additionally confirmed how the upper valence cations, Ca2+, trigger smaller gels to type relative to low valence cations Na(1)+.
As soon as you place all of this collectively, you successfully get a scenario like this inside the cells which permits small secretions of calcium there to shift its water from a fluid to a gel state.
Conversely, if the physique can disperse the gels, it additionally wants a method to recreate them. The first robust (excessive valence) anion it makes use of to construct them are the phosphates in adenosine triphosphate (ATP).
After we contemplate this different perform of ATP, we should always contemplate among the concepts first proposed by Ling (see 8.4 on web page 178). They recommend that a lot of the power obtained from ATP arises not from the power inside its bonds being damaged, however relatively from it inducing water to type a liquid crystalline construction. In essence, a lot of the power generated from ATP finally arises from the radiant power which triggers these polymerizations (gels).
Section transitions are quite common in mobile biology, and whereas the sector doesn’t place a heavy emphasis on their significance, Pollack’s central argument in his first two books is that part transitions are needed to clarify many capabilities of the cell.
Be aware: Once I later mentioned my articles with Pollack, he knowledgeable me that the primary oversight together with his earlier analysis was that that they didn’t but know that the gels had been negatively charged, which in flip explains quite a lot of the consequences they create (e.g., {the electrical} impulse of nerves).
Increasing Gels
One of many major makes use of for gels inside the physique is from them to quickly increase and create results from that enlargement. For instance, cells often excrete small spheres (often called vesicles) containing necessary elements, which upon exiting the cell quickly increase. Remoted mucin-producing vessels for instance endure a 600 fold enlargement in 40 milliseconds.
Previous to exiting the cell, the interior elements of the vesicle are cross linked collectively by Ca2+ (bear in mind, increased valence cations, by means of crosslinking gel proteins, will restrict gel formation whereas monovalent cations like sodium as an alternative are inclined to increase them).
As soon as secreted from the cell, Ca2+ is eliminated and the gel quickly hydrates within the Na(1)+ answer surrounding every cell. Conversely, gels is not going to quickly increase in distilled water, and it has been noticed that liquid crystalline water’s formation can also be diminished inside deionized water.
Be aware: Some vesicles make the most of native environmental elements to alter their part. For instance, histamine is a monovalent cation (cost of +1) at a impartial pH, however turns into a divalent cation (cost of +2) in an acidic pH. Researchers had been in a position to present that histamine in an acidic setting (as a result of its excessive valence state), causes shrinking of mast cell granules, whereas histamine in a impartial setting permits their enlargement.
Muscle Physiology
Most of the most typical issues for which sufferers search out physicians originate from the muscle tissue. Due to this, I’ve checked out a variety of other ways to deal with these points. In flip, I’ve discovered fairly a couple of that constantly work however I can’t clarify why as the present mannequin of muscle physiology can’t present a proof.
One of many main issues with medication (and sometimes science) is what I time period the “mechanistic entice.” Briefly it implies that if there may be not a mechanism to clarify why one thing works, then it’s assumed to be a hoax and thought to not truly work. I feel this compulsive want for a mannequin is sort of silly, particularly since most of the fashions we make the most of to clarify why medication work, don’t truly make sense.
Equally, there are lots of instances of a beforehand accepted mannequin for a drug’s mechanism that was discarded and changed with one other, and I do know of many extra examples the place an unorthodox mannequin seems to offer a a lot better clarification for the mechanism of a remedy.
Be aware: This additionally holds true for a lot of different non-drug therapies.
Sadly, it’s practically not possible to have the FDA (or many conventionally skilled physicians) be open to contemplating a remedy for analysis except a biochemical mechanism for it’s proposed. I consider it is a reflection of the very fact pharmaceutical medication, as they’re designed to focus on sure enzymes within the physique, match into our inflexible mechanistic paradigm, whereas therapies with a broad spectrum of motion can’t be linked to a selected biochemical receptor nor as simply profited from.
Given all of this, I used to be overjoyed to find by means of Pollack that many elements of the present mannequin for muscle physiology don’t make sense, and the anticipated outcomes of the mannequin don’t happen when rigorous experiments on muscle tissue are carried out:
Nonetheless, an alternate mannequin for muscle physiology additionally exists. As we contemplate it, we should always remember that muscle tissue are acknowledged to solely be able to contracting. Within the situations the place one thing within the physique wants to elongate, that is achieved by having a muscle in the precise place shorten, and as a result of its place, create a lengthening some other place by means of doing so (e.g., the triceps within the arm).
From Pollack’s work, I noticed that whereas muscle tissue can solely create drive throughout a contraction, that is truly a results of the very fact their elements can solely forcefully lengthen.
Pollack’s mannequin is predicated on the statement that relaxed muscle tissue include a considerable amount of structured water, whereas contracting muscle tissue primarily include water not in a semisolid gel state. Since it’s identified that muscle firing follows the nerve sign directing calcium (Ca2+) ions to enter the muscle, this means a calcium induced part change could underlie the method.
Conversely, it is usually identified (from the experiment beforehand described within the gradient part) that whereas muscle cells which have been reduce open can retain their potassium to sodium gradient whereas in a salt answer, the components that lack ATP are unable to.
This means that ATP is critical for the liquid crystalline state of water to be current, because it excludes sodium ions from getting into the muscle cells. Equally, it is usually identified that with out ATP, muscle tissue will stay caught within the contracted type and be unable to elongate, one thing that happens shortly after demise (termed “rigor mortis”).
Be aware: One of many compelling anecdotal tales I’ve heard over time is that when severely vaccine-injured youngsters die (e.g., these with lifelong debilitating autism) rigor mortis units in a lot quicker for them. Those that noticed this advised that these youngsters had a persistent power deficit, and their our bodies had been struggling to make sufficient ATP to get by. I feel that is very doable, nevertheless it may be indicative of poor zeta potential.
I think this may additionally be seen with different persistent debilitating diseases, however I’ve not interacted with the individuals who would have noticed if it did in truth happen.
Pollack additionally noticed that muscle modifications in response to environmental elements adopted a well-recognized essential threshold being handed. This additionally appeared to recommend to Pollack {that a} part change was occurring inside the muscle tissue.
So what’s Pollack’s mannequin? The muscle tissue fibers are designed to type giant gels round them, and as liquid crystalline water inside them expands, it stretches the uncoiled proteins within the fibers into helixes (till protein cross hyperlinks stop additional stretching). When the muscle must contract, calcium ions enter the muscle, eliminating the gels, and the proteins not being lengthened elastically snap again to their unique uncoiled configuration.
To ensure that the gel to rebuild, ATP is required to interrupt the cross hyperlinks created by calcium and thereby set off a part shift that reconstructs the gel.
Thus, the power of a muscle is a product of the potential power created by liquid crystalline water’s storage of radiant power being launched. Or put otherwise, the power of muscle tissue truly lies of their means to spontaneously lengthen and explains why many efficient muscular remedies I’ve come throughout work.
Massive mechanical shear causes the cytoskeleton matrix [another key structure that expands and contracts in response to phase changes] to fluidize, a phenomenon much like bodily rejuvenation in SGM’s [certain synthetic materials]. This fluidization is adopted by a sluggish scale- free restoration of mechanical properties, a phenomenon much like bodily ageing in SGMs.
Surprisingly in response to a transient stretch, the cytoskeleton fluidizes in a sample that’s common for various cell varieties. This discovering implicates mechanisms mediated not a lot by particular signaling pathways, as it’s often assumed, however relatively – as we clarify beneath – by non-specific actions of bodily forces.
Many different constructions even have the flexibility for his or her inside gels to trigger enlargement and contraction, however not like skeletal muscle tissue, typically, this enlargement and contraction isn’t as tightly constrained as what’s noticed inside the closely cross-linked skeletal muscle tissue.
Clean muscle tissue, in addition to contractile rings, artificial actin gels (actin is likely one of the most typical contractile proteins within the physique), and different organelles with few covalent cross hyperlinks and semi-random constructions are different examples of locations the place the physique makes use of this precept to maintain life.
Lastly, it has additionally been noticed that altering the encircling concentrations of salinity round different fibers (e.g., collagen) could cause them to increase and contract to the purpose they’ll generate a drive yielding contraction much like that of a muscle fiber.
Conclusion
There have been a couple of central questions I’ve sought to handle in my exploration of liquid crystalline water. On this sequence, I sought a mechanism to clarify the statement in quite a few conventional medical methods that an inherent expansive drive exists all through the physique which performs a key function in offering its vitality and that when this expansive drive is compromised, quite a lot of illnesses set in.
I agree with this perception and have seen quite a few situations the place it grew to become doable to acknowledge the place that life sustaining enlargement had been changed with a decent compacted area, and likewise seen strategies that sought to revive that enlargement additionally restore a affected person’s vitality.
Conversely, I consider the lack of mobility and sturdiness that accompanies ageing (and one of many largest issues to elder sufferers) is instantly associated to the lack of liquid crystalline water we usually expertise with age.
On this article, I’ve tried for instance the structural results of liquid crystalline water inside the physique, and it’s my hope that by means of doing so, I’ve offered a mechanism to clarify the place that expansive drive originates from. Within the subsequent a part of this sequence, I clarify how water’s liquid crystalline state creates a gradient that may be harvested for power and creates the circulation life relies upon upon.
Within the article after that, I did my greatest to clarify the intertwined relationship between liquid crystalline water and zeta potential, and within the remaining a part of this sequence I mentioned the strategies I’ve come throughout which seem to revive both.
Every of those matters is sort of advanced (e.g., this text was a synthesis of quite a few books and articles), however in my view nonetheless essential to dive into for unravelling the mysteries of life. In flip, it’s my honest hope the widespread awakening that has occurred in our society because of COVID-19 can rekindle curiosity to discover unconventional topics like this.
I thank every of you for the eye you gave in making an attempt to understanding this comparatively advanced matter which is close to and expensive to my coronary heart. I sincerely hope that you can also undertake a few of its implications into your each day life.
A Be aware From Dr. Mercola In regards to the Creator
A Midwestern Physician (AMD) is a board-certified doctor within the Midwest and a longtime reader of Mercola.com. I admire his distinctive perception on a variety of matters and I am grateful to share them. I additionally respect his want to stay nameless as he’s nonetheless on the entrance traces treating sufferers. To seek out extra of AMD’s work, make sure you try The Forgotten Facet of Drugs on Substack.
